| 2021-07-24 15:30 | IK Sirius FK vs Degerfors IF |
| 2021-07-24 15:30 | SC FC Voluntari SA vs FC Botosani |
| 2021-07-24 15:30 | Jagiellonia Bialystok vs Lechia Gdansk |
| 2021-07-24 15:45 | Botev Plovdiv vs Pirin Blagoevgrad |
| 2021-07-24 16:00 | Slask Wroclaw vs Warta Poznan |
| 2021-07-24 16:00 | Legia Warsaw vs Wisla PLock |
| 2021-07-24 16:00 | Gornik Leczna vs KS Cracovia |
| 2021-07-24 16:00 | Bruk-Bet Termalica vs Stal Mielec |